LUPINIB 400 mg Tablet
Uses of LUPINIB 400 mg Tablet
LUPINIB; to treat chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL) that are Philadelphia chromosome-positive (Ph+) and certain types of gastrointestinal stromal tumors (GIST), systemic mastocytosis, and myelodysplastic syndrome.
How it Work
Imatinib Mesylate is a specific inhibitor of a number of tyrosine kinase enzymes. It occupies the TK active site, leading to a decrease in activity.In this condition the white blood cells start growing out of control so Imatinib is used to inhibit the growth of these cells. Hence cures leukaemia.
Common Side Effects
Common side effects include; Acne-like rash is reported very commonly. Other common adverse effects include: diarrhoea, nausea, vomiting, anorexia, hair loss.
Moreover,
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*Follow your doctor’s advice.
*Always take medicine after food.
*Take the medicine with water.
Fast Fact
As Imatinib Mesylate is a selective chemotherapeutic agent, its tolerability profile is better than previous cytotoxic agents. Adverse drug reactions (ADRs) are acceptable for a potentially fatal disease.
Frequently Asked Question
Tyrosine kinases present attractive drug targets for specific types of cancers. Gleevec, a well-known therapeutic agent against chronic myelogenous leukemia, is an effective inhibitor of Abl tyrosine kinase. However, Gleevec fails to inhibit closely homologous tyrosine kinases, such as c-Src.
- clarithromycin, chloramphenicol, ketoconazole, ritonavir and nefazodone.
- itraconazole, clarithromycin, grapefruit juice.
- simvastatin, ciclosporin, pimozide, warfarin, metoprolol.
- paracetamol.
Imatinib is a cytotoxic drug which works by inhibiting the growth of abnormal cells in Philadelphia chromosome-positive acute lymphoblastic leukaemia. In this condition, the white blood cells start growing out of control so Imatinib is used to inhibit the growth of these cells.
Common combination chemotherapy regimens
| Cancer type | Drugs |
|---|---|
| Breast cancer | Cyclophosphamide, methotrexate, 5-fluorouracil, Doxorubicin, Gefitinib |
| Hodgkin’s disease | Docetaxel, doxorubicin, cyclophosphamide, Doxorubicin, bleomycin, vinblastine, dacarbazine |
| Non-Hodgkin’s lymphoma | Cyclophosphamide, doxorubicin, vincristine, prednisolone |
| Germ cell tumor | Bleomycin, etoposide, cisplatin, |
| Stomach cancer | Epirubicin, cisplatin, capecitabine, 5-fluorouracil |
| Bladder cancer | Methotrexate, vincristine, doxorubicin, cisplatin |
| Lung cancer | Cyclophosphamide, doxorubicin, vincristine, Gefitinib, Erlotinib |
| Colorectal cancer | 5-fluorouracil, folinic acid, oxaliplatin |
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