Metformin is the first-line medication for the treatment of type 2 diabetes, other Medical uses are Prediabetes, .It is on the World Health Organization’s List of Essential Medicines, the most effective and safe medicines needed in a health system. Metformin is believed to be the most widely used medication for diabetes which is taken by mouth. Metformin is generally well tolerated. Metformin is in the biguanide class. It works by decreasing glucose production by the liver and increasing the insulin sensitivity of body tissues. and glimepiride Belongs to the class of sulfonylureas. Used in the treatment of diabetes.